Head to head
Methylene blue vs Vitamin B12
On the strength of human evidence, Vitamin B12 comes out ahead (evidence 55 vs 20). But they're often used for different things — read each claim before deciding.
Methylene blue
▲ Trendingthe widest hype gap on this list
Marketing intensity 95 of 100. Evidence strength 20 of 100. Verdict: Severely overhyped.
A century-old medical dye with interesting mechanisms, almost no long-term human evidence for the biohacker claims, and real, specific dangers if you take antidepressants.
Full evidence on Methylene blue →Vitamin B12
Moderatean energy fix only if you're actually low
Marketing intensity 75 of 100. Evidence strength 55 of 100. Verdict: Slightly overhyped.
Essential and genuinely energising if you're deficient. The 'B12 for energy' shots and gummies do nothing measurable if your levels are already normal.
Full evidence on Vitamin B12 →Side by side
| Metric | Methylene blue | Vitamin B12 |
|---|---|---|
| Overall tier | Weak | Moderate |
| Evidence score | 20/100 | 55/100 |
| Hype score | 95/100 | 75/100 |
| Verdict | Severely overhyped | Slightly overhyped |
| Safety concern | high | low |
Quick answers
Methylene blue or Vitamin B12 — which has better evidence?
On the strength of human evidence, Vitamin B12 comes out ahead (evidence 55 vs 20). But they're often used for different things — read each claim before deciding.
Can you take Methylene blue and Vitamin B12 together?
This page compares the evidence, not interactions. Some supplements interact with each other or with medications — check each one's safety section and talk to a pharmacist before stacking.